Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.

ABSTRACT:

Background

Suicidal ideation (SI) is associated with increased morbidity and is one of the main modifiable risk factors for suicide. While initial evidence indicates the efficacy of several treatments for SI, most treatments were not developed to specifically target SI and are often associated with side effects or high relapse rates. Limited understanding of the neurophysiological basis of SI has hindered the optimization of these treatments.

Methods

This systematic review synthesizes the evidence on neurophysiological biomarkers associated with treatment-induced changes in SI in the context of clinical trials. A systematic literature of the Embase, PubMed, and PsycInfo databases was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses

SUBMITTER: Stapper N 

PROVIDER: S-EPMC12623415 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature