Practicability of Activating Transcription Factor 3 as a Serological Marker for Severity Appraisal and Outcome Anticipation in Acute Supratentorial Intracerebral Hemorrhage: A Two-center Observational Analytical Study.

ABSTRACT:

Background

Activating transcription factor 3 (ATF3) is a neuroprotective factor and participates in acute brain injury. Here, we intend to determine whether serum ATF3 levels are associated with the severity and clinical outcomes of acute intracerebral hemorrhage (ICH).

Methods

In this two-center observational analytic study of 236 patients with supratentorial ICH and 114 controls, serum ATF3 levels were quantified at the admission of all patients, at study entry of all controls, and at serial time-points of 114 patients from all patients. The Admission National Institutes of Health Stroke Scale (NIHSS) and hematoma volume, and the modified Rankin Scale (mRS) at post-ICH six months were recorded. Outcome variables were stroke-associated pneumonia (SAP), early neurological de

SUBMITTER: Gu Y 

PROVIDER: S-EPMC12623450 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature