Control of flagellar gene expression by a chemotaxis receptor-like regulator in pathogenic Escherichia coli.

ABSTRACT: Chemoreceptors enable bacteria to modulate their swimming behavior in response to the perceived environmental cues. Despite the large diversity of stimuli sensed by bacterial chemoreceptors, their output to the chemotaxis pathway that controls the flagellar motor typically converges on a few conserved signaling proteins. Here, we characterize a unique chemoreceptor-like protein, Tls, which is found in the B2 phylogroup of Escherichia coli that includes many extraintestinal pathogenic (ExPEC) strains. Instead of mediating chemotactic signaling, Tls controls motility by repressing the expression of flagellar genes, and thus cell motility, through sequestration of the transcriptional master activator of flagellar genes, FlhDC. The subcellular localization of Tls, the sequestration of FlhDC, a

SUBMITTER: Lee JW 

PROVIDER: S-EPMC12623472 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature