Risk factors associated with beta-peripapillary atrophy in individuals of African ancestry with primary open-angle glaucoma.

ABSTRACT:

Background

Beta-Peripapillary Atrophy (beta-PPA) is an optic nerve head change associated with primary open-angle glaucoma (POAG). We evaluated demographic, ocular, and genetic risk factors for beta-PPA in individuals of African ancestry with POAG.

Methods

POAG cases were recruited from the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study. Beta-PPA was defined as hypopigmentation with visible choroidal vessels and sclera adjacent to the optic disc. Univariable and multivariable regression models assessed risk factors for the presence and extent of beta-PPA.

Results

Among 3381 eyes, 969 (28.6%) had beta-PPA. Beta-PPA was associated with older age (OR = 2.90, p < 0.001) and larger vertical cup-to-disc ratio (CDR) (OR = 1.58, p = 0.007), and was less

SUBMITTER: Sapir T 

PROVIDER: S-EPMC12623487 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature