Intact corticostriatal function in aged system x_c^- - deficient mice.

ABSTRACT: System x_c^- (with xCT as specific subunit) is an astrocytic cystine/glutamate antiporter that constitutes the major source of extracellular glutamate in the mouse striatum. We previously reported that young-adult mice lacking xCT (xCT^-/- mice) display decreased intracellular glutamate levels in pre- and post-synaptic compartments at corticostriatal synapses as well as impaired corticostriatal neurotransmission, compared to wildtype (xCT^+/+) littermates. These changes were accompanied by increased repetitive behavior and reduced social interaction, typical behaviors related to autism spectrum disorder (ASD). Although ASD is reported to be associated with atypical brain aging, we recently showed that xCT^-/- mice are protected against age-

SUBMITTER: De Pauw L 

PROVIDER: S-EPMC12623495 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature