Short-Term Outcomes and Immunologic Mechanisms of Adrenocorticotropic Hormone in Infantile Epileptic Spasm Syndrome: A Multicenter Prospective Trial in Southern China.

ABSTRACT:

Introduction

Adrenocorticotropic hormone (ACTH) is a first-line drug and standard therapy in infantile epileptic spasm syndrome (IESS) with different response rates. The mechanism of ACTH for treatment of IESS remains incompletely understood. This study aimed to evaluate short-term outcomes and immunologic mechanisms of ACTH in treating pediatric patients with IESS.

Methods

A multicenter prospective trial of pediatric patients with IESS treated with ACTH over 2 weeks was performed. Short-term responders were defined as those with resolution of epileptic spasms and hypsarrhythmia (if present) at day 14 without epileptic spasm recurrence over 30 days after ACTH therapy, while non-responders included those with persistent spasms or hypsarrhythmia after treatment, or recurrence

SUBMITTER: Ran Y 

PROVIDER: S-EPMC12623540 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature