Serum miR-200c-3p and miR-6134 as diagnostic biomarkers for epithelial ovarian cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) regulate gene expression and are emerging as biomarkers for epithelial ovarian cancer (EOC). We evaluated the diagnostic performance of serum miR-200c-3p and miR-6134, alone and in combination with established markers, to distinguish EOC from benign ovarian tumors and healthy controls.

Methods

In this single-center, retrospective study, sera were collected from patients with EOC (N = 95), benign tumors (N = 115), and healthy controls (N = 40). Candidate miRNAs were screened by microarray and quantified by real-time PCR. Serum CA125, HE4, and IL-6 were measured by ELISA. Receiver operating characteristic curves and area under the curve (AUC) values were used to assess diagnostic performance.

Results

Both miR-200c-3p and miR-6134 were signi

SUBMITTER: Kawahara R 

PROVIDER: S-EPMC12623544 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature