ER stress induced extracellular vesicles secretion from macrophages promotes calcium oxalate crystals formation in kidney.

ABSTRACT: Macrophages are involved in the development of kidney stone disease, and substantial research suggests that macrophage-derived extracellulr vesicles (Mφ-EVs) may play a pivotal role in this process. However, the impact of Mφ-EVs on kidney stone formation and the mechanisms of EVs secretion remain unclear. Here we found that calcium oxalate (CaOx) crystals stimulation leads to increased inflammation and enhanced secretion of extracellular vesicles (EVs) in macrophages. Interestingly, these EVs can be absorbed by renal cells, significantly promoting renal tubular damage and facilitating the formation of CaOx crystals in mouse kidneys. Mechanistically, CaOx crystal stimulation activates endoplasmic reticulum stress (ERS)-related proteins, particularly PKR-like ER kinase (PERK), resulting in t

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC12623569 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature