Comparative Efficacy of Double-Filtration Plasmapheresis Versus Intravenous Methylprednisolone in Acute Attacks of Neuromyelitis Optica Spectrum Disorder: A Prospective Cohort Study.

ABSTRACT:

Introduction

While double-filtration plasmapheresis (DFPP) and intravenously administered methylprednisolone (IVMP) are both established treatments for acute attacks of neuromyelitis optica spectrum disorder (NMOSD), their comparative efficacy and safety profiles remain a critical area of investigation. This study aimed to evaluate the clinical outcomes and adverse events of DFPP versus IVMP in patients with NMOSD, with a focus on disability improvement and treatment tolerability.

Methods

A prospective single-center cohort study was performed with 146 patients with NMOSD, who were treated with DFPP, IVMP, and combination therapy (DFPP + IVMP). Primary efficacy was measured by changes in Expanded Disability Status Scale (EDSS) scores (ΔEDSS). Secondary outcomes included Modif

SUBMITTER: Ai X 

PROVIDER: S-EPMC12623573 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature