Transcriptional programs activated by exposure of human prostate cancer cells to androgen.

ABSTRACT:

Background

Androgens are required for both normal prostate development and prostate carcinogenesis. We used DNA microarrays, representing approximately 18,000 genes, to examine the temporal program of gene expression following treatment of the human prostate cancer cell line LNCaP with a synthetic androgen.

Results

We observed statistically significant changes in levels of transcripts of more than 500 genes. Many of these genes were previously reported androgen targets, but most were not previously known to be regulated by androgens. The androgen-induced expression programs in three additional androgen-responsive human prostate cancer cell lines, and in four androgen-independent subclones derived from LNCaP, shared many features with those observed in LNCaP, but some differe

SUBMITTER: DePrimo SE 

PROVIDER: S-EPMC126237 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature