Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets.

ABSTRACT: Ovarian cancer (OC) is a highly aggressive malignancy in women, and platinum resistance remains a major clinical obstacle. p53 mutations are prevalent in OC and exhibit functional heterogeneity that is associated with therapeutic response and disease progression. However, the roles and mechanisms underlying the functional heterogeneity of p53 mutations in platinum-resistant OC remain elusive. This investigation delineated that p53 mutations within the Loop 2, Loop 3, and β-strand S10 regions were closely linked to platinum resistance. In particular, functional assays unveiled that p53^R175H and p53^R175G mutations at Arg175 revealed distinct roles in tumor cell migration and drug resistance, with p53^R175G conferring resistance to agents targeting p53^R175

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12623820 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature