Effects of Non-Aspirin Nonsteroidal Anti-Inflammatory Drugs on Acute Intracerebral Hemorrhage.

ABSTRACT:

Objective

Despite celecoxib, a cyclooxygenase-2 inhibitor, promoting functional recovery from intracerebral hemorrhage (ICH) by reducing inflammation-mediated perihematomal edema in rat models, the evidence of its effects on patient outcomes remains limited. As nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate inflammation by inhibiting cyclooxygenase-2, this study aimed to assess the impact of non-aspirin NSAIDs on ICH outcomes.

Methods

Patients with acute ICH admitted to our hospital between January 2015 and December 2020 were prospectively enrolled and retrospectively categorized based on pre- or post-ICH use of non-aspirin NSAIDs. Outcomes were assessed using the modified Rankin Scale (mRS) score at 3 months, survival at 1 year, and mortality at long-term follow-up

SUBMITTER: Yeh SJ 

PROVIDER: S-EPMC12623835 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature