Effects of caffeine on neuroinflammation in anxiety and depression: a systematic review of rodent studies.

ABSTRACT: Anxiety and depression are the most prevalent mental illnesses in the contemporary world. Several animal models have been developed to understand the cellular and molecular mechanisms underlying these disorders and the effect of drugs in modulating the associated behavioral responses. Neuroinflammation has been related to mood disorders. Caffeine is a psychoactive substance that acts as a nonspecific blocker of adenosine receptors. Adenosine receptors are present in neurons and glial cells in different brain areas that are involved in controlling anxiety and depression. However, depending on the context, caffeine can exacerbate or inhibit neuroinflammation and behavioral responses associated with these conditions. This systematic review aimed to evaluate the effects of caffeine and related

SUBMITTER: da Silva Neves L 

PROVIDER: S-EPMC12623897 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature