Effect of solvent evaporation on the liquid-crystalline order of itraconazole.

ABSTRACT: Solvent evaporation is widely used for the formation of amorphous active pharmaceutical ingredients. This study investigates the effect of solvent evaporation on the structure of itraconazole - an antifungal drug and a model thermotropic liquid crystal that exhibits nematic and smectic phases when supercooled from the melt, and when cooled below the glass transition temperature at ~ 330 K, it forms glass with frozen liquid-crystalline order. Using X-ray scattering, it is demonstrated that the solid form of itraconazole obtained at room temperature via evaporation of dichloromethane reveals a smectic order extending up to ~ 15 nm, which is about two times more than what is observed for itraconazole glass obtained by the conventional vitrification. Moreover, the degree of the smectic order m

SUBMITTER: Lamrani T 

PROVIDER: S-EPMC12623910 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature