A non-invasive, flexible, lightweight, and wearable system for real-time ECG monitoring in freely moving mice.

ABSTRACT: ECG monitoring in mice is an essential tool for assessing physiological health. However, acquiring high-quality ECG signals from freely moving and conscious mice has remained a significant technical challenge. This study presents a non-invasive wearable real-time ECG monitoring platform for mice, integrating hollow ultra-flexible electrodes with a soft wireless circuit system, enabling high-fidelity real-time ECG monitoring during free activity. Using microfabrication and transfer techniques, we developed ultra-flexible electrodes that are scalable for large-area manufacturing and customizable to specific requirements. These electrodes conform tightly to the surfaces of the mouse's heart, abdomen, and limbs, enabling high-quality ECG signal acquisition. Even under 40% strain, the electrode

SUBMITTER: Yao Y 

PROVIDER: S-EPMC12623942 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature