Estimating homeostasis model assessment for insulin secretion by using multiple adaptive regression spline in healthy Taiwanese men.

ABSTRACT: The prevalence of type 2 diabetes (T2M) has been increasing drastically in recent two decades. One of the main underlying pathophysiology was decreased insulin secretion (ISEC). Even though there were many studies found the related factors affecting ISEC, no study used multiple adaptive regression spline (MARS) to build an equation estimating ISEC. In the present study, we used MARS to estimate hemostasis assessment model of β-cell (HOMA-β) in healthy Taiwanese men. Totally, there were 317 men enrolled. Participants who were taking medications related to metabolic syndrome were excluded. MARS was used to build an equation to estimate HOMA-β. Multiple linear regression (MLR) was taken as a bench mark for comparing the accuracy with MARS. The method with less estimation errors was considered

SUBMITTER: Ma CH 

PROVIDER: S-EPMC12623959 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature