Associations between genetic variations of HLA and IGHV, vaccination schedule, and COVID-19 vaccine immunogenicity.

ABSTRACT: Interindividual genetic variations significantly influenced SARS-CoV-2-specific immunogenicity after vaccination, particularly for human leukocyte antigen (HLA) alleles. However, the mechanisms of different HLA alleles with varying immunogenicity and additional genetic factors related to immunogenicity remained unexplored. This population-based study utilized data of 180,580 vaccinated individuals from the UK Biobank. A genome-wide association study was conducted to identify significant single nucleotide polymorphisms (SNPs) associated with COVID-19 vaccine immunogenicity, identified by immunoglobulin antibody result. We found that SNPs significantly associated with immunogenicity of COVID-19 vaccines were located near the HLA-DQ and IGHV1-69. We further determined HLA-peptide-binding affi

SUBMITTER: Ke L 

PROVIDER: S-EPMC12623965 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature