Molecular mechanisms of olanzapine against agitation in schizophrenia and bipolar disorder based on network pharmacology and molecular docking.

ABSTRACT: Olanzapine, a second-generation antipsychotic, is commonly used to manage agitation in patients with schizophrenia and bipolar disorder, though its underlying mechanism of action remains unclear. In this study, network pharmacology and molecular docking were applied to explore the potential molecular mechanisms of olanzapine. Targets related to olanzapine were retrieved from GeneCards, SwissTargetPrediction, and the Comparative Toxicogenomics Database (CTD), while disease-associated targets were collected from DisGeNET and GeneCards. A protein-protein interaction (PPI) network was constructed to identify key targets. Functional enrichment analyses using the Database for Annotation, Visualization and Integrated Discovery (DAVID) and Bioinformatics platforms indicated involvement in cell pro

SUBMITTER: Shi X 

PROVIDER: S-EPMC12623990 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature