Altered white matter microstructure of language pathways and semantic cognition deficiencies in early psychosis.

ABSTRACT: Semantic language dysfunction is a hallmark of early psychosis, yet the underlying brain structural correlates are largely unexplored. In particular, it is unclear whether core deficits arise from disruptions to semantic representation, which refers to the stored knowledge of word meanings, or to semantic control, which entails top-down mechanisms that guide the retrieval and selection of context-appropriate semantic information. By dissociating semantic representation-related from semantic control-related performance, we aimed to identify the preferential impairment in early psychosis and its structural correlates in the ventral and dorsal language streams. We investigated N = 120 individuals across the psychosis spectrum: N = 40 individuals with early psychosis, N = 40 individuals with h

SUBMITTER: Surbeck W 

PROVIDER: S-EPMC12624064 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature