Synergistic effects of body fat percentage and C-reactive protein triglyceride-glucose index on cardiovascular disease risk: a Chinese cohort study.

ABSTRACT: Obesity, insulin resistance (IR), and inflammation are key modifiable cardiovascular disease (CVD) risk factors. We investigated the synergistic effects of body fat percentage (BFP) and the C-reactive protein-triglyceride-glucose index (CTI) on CVD risk. This prospective cohort included 6303 CVD-free Chinese adults (≥ 45 years) from the CHARLS. BFP was calculated via the CUN-BAE equation; the CTI integrates CRP, triglycerides, and fasting glucose. Multivariate Cox regression was used to assess associations with incident CVD over 7 years. Mediation and receiver operating characteristic (ROC) analyses were used to evaluate pathways and predictive performance. Among 1124 incident CVD cases, concurrent high BFP (> 30.8%) and CTI (> 4.68) showed 1.48-fold higher CVD risk (95% CI 1.21-1.80) vers

SUBMITTER: Tian X 

PROVIDER: S-EPMC12624090 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature