Integrated genetic and epigenetic analysis identifies that rs939408 affects non-smoking lung adenocarcinoma risk by modulating the DNA methylation of LRRC2.

ABSTRACT: This study aimed to investigate the relationship between methylation quantitative trait loci (meQTL) and lung adenocarcinoma (LUAD) susceptibility. Candidate SNPs linked to differentially methylated CpG sites in LUAD were identified through meQTL datasets. Genome-wide association study (GWAS) data were analyzed to assess the correlation between selected meQTLs and LUAD risk. The effects of target genes on malignant LUAD phenotypes were examined through both in vitro and in vivo experiments. Additionally, machine learning and radiomics models were employed to evaluate the association of target genes on LUAD progression. The variant A allele of rs939408 was associated with decreased methylation levels of cg09596674 in LRRC2 (β < 0, P < 0.001). While cg09596674 was highly methylated, LRRC2 sh

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12624109 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature