Network pharmacology and molecular docking reveal multi-target mechanisms of Butea monosperma stem bark extract in ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC) is a chronic inflammatory disorder primarily affecting the colonic mucosa and submucosa. Butea monosperma stem bark is traditionally used in Ayurveda for diarrhea, inflammatory diseases, and Grahani Roga, which shares similarities with UC. However, the molecular mechanisms of B. monosperma in UC are unexplored. This study aimed to predict the molecular mechanisms of B. monosperma in UC by integrating network pharmacology, molecular docking, and dynamics-the first systematic effort to decode its phytochemical-target-pathway interactions, bridging traditional knowledge with computational pharmacology. A standardized B. monosperma stem bark was prepared. LC-MS analysis was used to identify phytochemicals in the stem bark, and their potential targets, along with disease

SUBMITTER: Mondal S 

PROVIDER: S-EPMC12624123 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature