Follow-up of osteonecrosis in paediatric acute lymphoblastic leukaemia patients treated with the NOPHO ALL2008 protocol.

ABSTRACT: Although osteonecrosis (ON) is a common sequel after childhood acute lymphoblastic leukaemia treatment and may cause debilitating symptoms, its prognosis remains underexplored. We describe the radiological evolution of ON lesions in a Finnish patient cohort treated according to the The Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol. We aimed to identify the factors influencing the outcome of ON. We collected data from 37 patients diagnosed with ON treated in five tertiary centres. We analysed magnetic resonance imaging scans containing 235 ON lesions (109 affecting joints) and graded them using the Niinimäki classification system. The mean follow-up time from an ON diagnosis was 3.3 years (SD 3.4 range: 0.04-13.5). Among the lesions with follow-up scans, 55%

SUBMITTER: Rokkanen R 

PROVIDER: S-EPMC12624161 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature