Has early mortality following single-unit unrelated cord blood transplantation improved in recent years? A nationwide registry data analysis from 2003 to 2022 in Japan.

ABSTRACT: Unrelated single-unit cord blood transplantation (CBT) is a valuable alternative donor source for patients without matched related or unrelated donors. Although initial concerns included limited cell dose, delayed haematopoietic recovery and higher early mortality, advancements in transplant practices may have led to improved outcomes. However, it remains uncertain whether these improvements extend to the most recent years. We conducted a nationwide, registry-based retrospective study of 15 816 patients who received unrelated single-unit CBT in Japan and analysed across four time periods: 2003-2007, 2008-2012, 2013-2017 and 2018-2022. Overall survival (OS) improved significantly across time periods, with 3-year OS increasing from 38.8% (2003-2007) to 54.4% (2018-2022; p < 0.001). Similarly

SUBMITTER: Konuma T 

PROVIDER: S-EPMC12624182 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature