European-based polygenic risk score and genome-wide association study of B-cell non-Hodgkin lymphoma subtypes in Israeli Jews and Palestinian Arabs.

ABSTRACT: Among individuals of European Ancestry (EA), genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) and polygenic risk scores (PRSs) associated with non-Hodgkin lymphoma (NHL) risk. We evaluated subtype-specific PRSs, based on established EA-SNPs, in Israeli Jews (IJ) and Palestinian Arabs (PA) and performed a GWAS in the combined ethnic groups to identify new loci. We included three common pathologically confirmed subtypes: diffuse large B-cell (DLBCL), follicular (FL) and marginal zone (MZL) lymphomas. Controls were frequency matched to cases by age and sex. Among 752 IJ (201-DLBCL; 130-FL; 54-MZL/367-controls) and 593 PA (203-DLBCL; 41-FL/349-controls), we computed PRSs weighted by EA-derived effect estimates and used logistic regression models adj

SUBMITTER: Kleinstern G 

PROVIDER: S-EPMC12624183 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature