A Five-Year Follow-Up Study on the Removal of Dental Amalgam Restorations (Bergen Amalgam Trial): Examining Potential Confounding Factors and Effect Modification.

ABSTRACT:

Background

This government-funded project comprised experimental treatment aimed at improving health and quality of life for individuals with health complaints attributed to dental amalgam.

Objectives

The objective was to evaluate long-term changes in health complaints and health-related quality of life (HRQoL) after amalgam removal in individuals attributing health issues to dental amalgam, while also assessing effect modification and confounding factors.

Methods

The project was designed as a prospective cohort study. Three cohorts were followed over time: an Amalgam cohort (treatment group, n = 32), a cohort of patients with medically unexplained physical symptoms (MUPS cohort, n = 28) and a cohort of healthy volunteers (Healthy cohort, n = 19). The Amalgam cohort i

SUBMITTER: Bjorkman L 

PROVIDER: S-EPMC12624185 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature