Impact of Intravascular Fluid Resuscitation on Whole Blood Viscosity During Endovascular Detachable Coiling Procedure for Unruptured Intracranial Aneurysm: A Prospective Randomized Controlled Trial.

ABSTRACT:

Background

Whole blood viscosity (WBV) determines wall shear stress, representing dynamic force and contributing to aneurysmal remodeling. We hypothesized that administering balanced crystalloid (Group-C) or hydroxyethyl starch (HES) 130/0.4 (Group-HES) for IV fluid management would have a different impact on high-shear WBV during the endovascular detachable coiling (EDC).

Methods

Thirty EDC patients randomly got HES (Group-HES, n = 15) or crystalloid (Group-C, n = 15) as the main IV fluid resuscitation during the procedure. The WBV at a shear rate of 300 sec^-¹ of arterial blood samples (WBV₃₀₀), which depict WBV at a larger-sized artery, were determined and analyzed before and after the EDC procedure (Pre and Post). The changes in hematocrit (Hct) and arterial-to

SUBMITTER: Oh CS 

PROVIDER: S-EPMC12624211 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature