Clinicopathological Features and Immunochemical Staining of Inflammatory Myofibroblastic Tumor: A Retrospective Study of 48 Cases.

ABSTRACT: Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms found in diverse anatomical sites, including the lungs, intestines, and bladder. Surgical resection is the primary treatment, with chemotherapy offering survival rates of 21.2 and 42.5 months in unresectable cases. Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) have emerged as standard treatments. However, IMT presents diagnostic challenges owing to its morphological similarities with other conditions. While positive ALK expression aids diagnosis in approximately 50% of the cases, negative ALK expression complicates diagnosis. This retrospective study reviewed 48 patients with IMT diagnosed at a Taiwanese medical center and analyzed their clinical characteristics, pathology reports, immunohistochemical (IHC)

SUBMITTER: Wang QA 

PROVIDER: S-EPMC12624268 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature