Fibroblast Has2 limits acute heart failure following myocardial infarction in male mice.

ABSTRACT: Changes to the extracellular matrix support acute wound healing following myocardial infarction. Fibroblasts regulate the composition of the extracellular matrix, in part, by secreting hyaluronan. Details surrounding the regulation, source, and impact of hyaluronan production after MI are largely unknown. We recently showed that activated fibroblasts produce hyaluronan via Has2; however, the extent to which this function impacts acute ventricular remodeling following myocardial infarction (MI) has not been tested. Hence, the goal of the present study was to elucidate the impact of fibroblast-borne Has2 expression in acute ventricular remodeling. Adult, male and female mice were subjected to non-reperfused myocardial infarction and followed for 1 week and subjected to echocardiography and h

SUBMITTER: Little DT 

PROVIDER: S-EPMC12624274 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature