First-Trimester Serum n-3/n-6 Fatty Acids Predict Large-for-Gestational-Age Risk: A Nested Case-Control Study.

ABSTRACT: Polyunsaturated fatty acids (PUFAs) are critical for fetal development during pregnancy. This study evaluates the association between maternal serum n-3 and n-6 PUFAs in early pregnancy and the risk of large-for-gestational-age (LGA) infants. A nested case-control study was conducted with 45 LGA-appropriate for gestational age (AGA) matched pairs from a cohort of 2839 pregnant women. Maternal serum samples collected during early pregnancy were analyzed for lipid profiles using gas chromatography-mass spectrometry (GC-MS). Associations between fatty acid levels and LGA risk were assessed using Spearman correlation, chi-square tests, and logistic regression. The results indicated that higher arachidonic acid (ARA, p = 0.024) and docosahexaenoic acid (DHA, p = 0.039) levels were positively co

SUBMITTER: Cai X 

PROVIDER: S-EPMC12624277 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature