Near-Infrared Conjugated Macrocyclic BODIPYs for Photothermal Cancer Therapy.

ABSTRACT: With this research we developed a cyclization strategy that effectively converts radiative transitions (RTs) to non-radiative transitions (NRTs) during the decay process of BODIPY-based photosensitizers. Compared to BODIPY monomers, cyclization leads to a significant decrease in the HOMO-LUMO energy gap and a significant increase in the HOMO energy. In particular, the absorption spectrum of 7a exhibits a significant redshift, with the maximum absorption wavelength reaching 794 nm. Photophysical characterization indicates that the macrocyclic BODIPY derivatives 7(a-d) exhibit a reduced RT process. While, the crystal structure and theoretical calculations suggest that the molecular ring distortion enhances the intersystem crossing (ISC) ability of the macrocyclic BODIPY derivatives 7(a-d). I

SUBMITTER: Cheng F 

PROVIDER: S-EPMC12624305 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature