Coordination-Driven Orthogonal Ligand Pairings through Dual Hydrogen-Bonding/π-π Interaction Complementarity.

ABSTRACT: Multi-layered and orthogonal recognition is an excellent route to controlled molecular complexity. Here we report a series of heteroleptic complexes where two ligands pair together at a palladium(II) metal centre in complementary fashion and with orthogonality to others pairs. This complementarity is driven in part through hydrogen-bonding acceptor or donor sites proximal to the coordination domain (either DD:AA or AD:DA). These interactions alone are insufficient to control ligand pairing identity and/or orientation-secondary π-π interactions between electron-rich and electron-poor aromatic groups in the recognition domain combine with the hydrogen bonding to give high levels of complementarity. Importantly, the different heteroleptic complexes can be combined without significant scrambli

SUBMITTER: Smith JN 

PROVIDER: S-EPMC12624320 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature