Electrochemical ⍺-C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles.

ABSTRACT: The synthesis of energetic materials (EMs) often involves hazardous reagents and harsh conditions, raising safety and environmental concerns. We herein present an electrochemical method for the ⍺-C─H azolation of nitramines, enabling the integration of nitramines and various nitrogen-rich azoles as dual energetic components within the same molecule. To enhance the practicality of the overall synthesis, we developed a tandem two-step process that transforms free amines into nitramines using stable and readily available reagents, which was complemented by subsequent electrochemical azolation to complete a streamlined, scalable preparation of bifunctional energetic compounds. Finally, a continuous flow system was employed to further improve the practicality of the electrosynthetic method, whi

SUBMITTER: Lee WC 

PROVIDER: S-EPMC12624331 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature