Lifestyle medicine and brain health: Insights from the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) and the promise of personalization.

ABSTRACT: The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) is a landmark 2-year randomized clinical trial evaluating multidomain lifestyle interventions for dementia prevention in older adults at elevated risk. Its effectiveness and national reach represent an important step towards scaling prevention science in diverse, real-world settings. However, the trial also underscores a persistent challenge in lifestyle medicine: the prioritization of feasibility over optimization. In this commentary, we review U.S. POINTER through a precision medicine lens and outline strategies to integrate standardized core elements with flexible, individualized components that can amplify both potency and applicability. We emphasize three priorities: (1) tailoring inter

SUBMITTER: Alfini A 

PROVIDER: S-EPMC12624361 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature