Derivation of a health-based guidance value for Δ⁸-tetrahydrocannabinol (Δ⁸-THC) and its occurrence in food.

ABSTRACT: The European Food Safety Authority (EFSA) was asked to deliver a scientific opinion on the derivation of a health-based guidance value (HBGV) for Δ⁸-tetrahydrocannabinol (Δ⁸-THC) in food with an assessment of the occurrence of Δ⁸-THC and the co-occurrence with Δ⁹-THC in hemp and hemp-derived products. Data from a clinical study were used to inform on the relative potency between Δ⁹-THC and Δ⁸-THC. The point estimate of the relative potency (ratio Δ⁹-THC/Δ⁸-THC) was in the range between 1 and 1.4, with 95% confidence between 0.97 and 1.63. Based on this range, the CONTAM Panel, using a conservative approach, set a relative potency factor of one for Δ⁸-THC. The CONTAM Panel had previously set a

SUBMITTER: EFSA Panel on Contaminants in the Food Chain (CONTAM) 

PROVIDER: S-EPMC12624367 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature