The First Isolation of Multiple Antifungal-Drug-Resistant Trichophyton Rubrum in China and the Novel Resistance Mechanism.

ABSTRACT:

Objectives

This study reports the first isolation of a multidrug-resistant Trichophyton rubrum strain in China, characterizing its drug resistance profile and mechanisms.

Methods

The isolate was identified by internal transcribed spacer (ITS) sequencing and phylogenetic analysis. In vitro antifungal susceptibility testing (AFST) was performed according to the M38-A3 CLSI guideline to determine minimum inhibitory concentrations (MICs) against eight antifungals (terbinafine, itraconazole, fluconazole, amorolfine, griseofulvin, voriconazole, luliconazole and amphotericin B). Whole genome sequencing (WGS), transcriptome sequencing and qRT-PCR were performed to explore the resistance mechanism.

Results

The multidrug-resistant T. rubrum strain L-6424 was isolated from a Chi

SUBMITTER: Song G 

PROVIDER: S-EPMC12624381 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature