Evaluating the impact of a 10 year reduction in critically important antibiotic use on the occurrence of antibiotic resistance in <i>E. coli</i> from cattle, dogs and cats in France.

ABSTRACT:

Objectives

In France, a 10 year national policy to reduce antibiotic use (ABU) in animals led, respectively, to an 88% and 94% decrease in animal exposure to fluoroquinolones and third- and fourth-generation cephalosporins (3GC-4GC) between 2011 and 2021.

Methods

Building on national surveillance data, this study evaluated the impact of this national policy on reducing the occurrence of resistance to fluoroquinolones and 3GC-4GC in clinical Escherichia coli from young cattle and dogs and cats in France. The effect of homologous and heterologous use of antibiotics was explored using multivariate regression modelling. In addition, the time lag between implementation of national policies and subsequent reduction in antibiotic resistance (ABR) was estimated using segmente

SUBMITTER: Collineau L 

PROVIDER: S-EPMC12624393 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature