Cholinergic white matter pathways integrity in prodromal and early manifest Lewy body disease.

ABSTRACT: Degeneration of the nucleus basalis of Meynert (NbM), the main cholinergic source to the cerebral cortex, has been demonstrated in advanced stages of Lewy body (LB) disorders. While the lateral and medial white matter pathways connecting the NbM to the cerebral cortex have been shown to be affected in LB patients with dementia, less is known regarding their vulnerability in prodromal and early manifest patients without significant cognitive impairment, and how their integrity relates to disease manifestation and progression. Here, we used diffusion MRI (dMRI) to examine whether changes in the microstructural integrity of the white matter tracts of the NbM are already evident in prodromal LB disease (namely, isolated rapid eye movement sleep behaviour disorder (iRBD), n = 67), and in

SUBMITTER: Eisenstein T 

PROVIDER: S-EPMC12624394 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature