Cannabinoid Receptors Modulate Physiological Remodelling of the Blood-Testis Barrier.

ABSTRACT: The endocannabinoid system, including the CB1 and CB2 receptors, has been associated with the modulation of blood-brain barrier and gut barrier. Herein, using CB1 knock-out male mice, we studied the potential role of these receptors in maintenance of blood-testis barrier (BTB) integrity during the seminiferous epithelium remodelling phase (Stages VIII-XI), focusing on events responsive to CB1 and CB2 activity. Our results showed that the genetic loss of CB1 disrupted testicular expression of some components of BTB, including factors of junctional complexes, promoting tubular infiltration of blood cells. Such infiltration specifically occurred at Stages VIII-IX transition. Gene expression analysis of molecular tags that highlight BTB remodelling (by addressing Occludin to early/late endosom

SUBMITTER: Manfrevola F 

PROVIDER: S-EPMC12624519 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature