Global trends, age-period-cohort analysis, and future projections of diarrhea burden: Findings from the Global Burden of Disease Study 2021.

ABSTRACT: Diarrhea is currently a prominent global public health issue. This study evaluated recent trends in the global burden of diarrhea and projected future changes over the next decade. Using the diarrhea data from the global burden of disease (GBD) 2021, this study assessed the temporal trends using Joinpoint regression and explored the impact of different factors using age-period-cohort modeling. Decomposition analysis identified drivers of disease burden changes, and the Bayesian age-period-cohort (BAPC) model predicted future trends. Additionally, health inequalities were measured by the inequality slope index and the concentration index. Results show a downward trend in the global burden of diarrhea since 1990. Age-period-cohort analysis suggests that the risk of incidence decreases with a

SUBMITTER: Xie M 

PROVIDER: S-EPMC12624536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature