Treatment of allergic rhinitis with a mixed Chinese herbal formula via regulatory B cells: A prospective pilot study.

ABSTRACT:

Background and aim

Mixed Chinese herbal formulas (CHFs) are commonly prescribed for allergic rhinitis (AR), but few studies explore their mechanisms. Prior research highlighted the immunomodulatory effects of a specific mixed CHF (Xin-yi-san + Xiao-qing-long-tang + Xiang-sha-liu-jun-zi-tang) in perennial AR by targeting neutrophils, dendritic cells, and CD4⁺ T lymphocytes. Here, we aimed to investigate the immunomodulatory mechanisms of mixed CHFs in treating AR by examining their effects on regulatory B (Breg) cells as a novel therapeutic approach.

Experimental procedure

In this 3-month prospective pilot study, we assessed the immunomodulatory effect of a mixed CHF on patients with perennial AR, comparing the high-IgE (H-IgE; total serum IgE ≥200 IU/mL) and low-I

SUBMITTER: Hsu PY 

PROVIDER: S-EPMC12624655 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature