Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights.

ABSTRACT: Rift Valley fever virus (RVFV) is an arbovirus from the Phenuiviridae family that can cause severe disease in humans and livestock, with outbreaks resulting in substantial economic losses. Despite the availability of attenuated vaccines for animals, there is no approved preventive or therapeutic agent for human RVFV infections. Moreover, the safety and efficacy of the current veterinary vaccines remain uncertain. The RVFV L protein, a 250 kDa polymerase, plays a key role in viral replication and transcription, containing endonuclease, RNA-dependent RNA polymerase (RdRp), and cap-binding domains. Structurally conserved across related viruses and functionally analogous to the influenza virus polymerase, the L protein is a compelling antiviral target. In our study, we screened a librar

SUBMITTER: Kral' M 

PROVIDER: S-EPMC12624712 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature