Mn(III) Porphyrin MnTE-2-PyP⁵⁺ Associated with Ascorbate: A Redox-Active Therapeutic Strategy against Leishmaniasis.

ABSTRACT: Toxicity and rising resistance to current leishmaniasis drugs highlight the need for alternative therapies. Manganese porphyrins (MnPs) have demonstrated therapeutic potential in various oxidative stress-based diseases/ailments due to their redox-modulating properties. Thus, this study aimed to evaluate the redox-active effects of MnTE-2-PyP⁵⁺ (BMX-010, AEOL10113, MnP ethyl) combined with ascorbate (Asc, vitamin C) on Leishmania amazonensis, Leishmania braziliensis, and Leishmania chagasi in vitro. The effects on promastigote growth were assessed, and the mechanism of action was studied by quantifying reactive oxygen species (ROS) and using catalase to evaluate H₂O₂ involvement. The effects on intracellular amastigotes and the mi

SUBMITTER: Souza THS 

PROVIDER: S-EPMC12624719 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature