Risk factors for severe outcomes of respiratory syncytial virus infection in children: a nationwide cohort study in Sweden.

ABSTRACT:

Background

While risk factors for respiratory syncytial virus (RSV) hospitalization are well established, few studies have assessed severe disease outcomes. We investigated risk factors for RSV-associated severe disease outcomes in children 0-18 years.

Methods

A register-based cohort study including all children born in Sweden between 2001 and 2022 was performed. Data on RSV related ICD-10 diagnoses, sociodemographic factors and comorbidities were retrieved from national registers. The outcomes were RSV-associated death, Intensive Care Unit (ICU) admission, and prolonged hospitalization (≥7 days). Adjusted hazard ratios (aHR) and 95% confidence intervals (CI) were calculated using multivariable Cox regression both in the full cohort and in the subpopulation of children with

SUBMITTER: Dallagiacoma G 

PROVIDER: S-EPMC12624800 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature