Prognostic Value of Right Ventricular Global Wasted Work in Precapillary Pulmonary Hypertension: A 3D Echocardiographic Study.

ABSTRACT:

Aim

Right ventricular (RV) function determines symptom burden and clinical outcomes in pulmonary hypertension (PH). Global wasted work (GWW) quantifies mechanical inefficiencies in RV performance associated with elevated afterload, but is inadequately characterized in precapillary PH. We assessed the association of GWW with echocardiographic indices of RV remodeling, RV-PA coupling and invasive hemodynamics, and evaluated its prognostic significance in precapillary PH.

Methods and results

Myocardial work indices were measured by 3D echocardiography in patients with well-defined precapillary PH who underwent right heart catheterization within 24 hours. Patients with poor image quality, significant valvular lesions and associated left heart disease were excluded. Among 61 pati

SUBMITTER: Venkateshvaran A 

PROVIDER: S-EPMC12624819 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature