Pd(0)-Mediated Deallylation Chemistry: A Reassessment of Its Application in Sensing CO.

ABSTRACT: Pd(0)-mediated deallylation has been employed for developing fluorescent probes for carbon monoxide (CO). The key idea relied on the ability of CO to reduce Pd(II) to Pd(0). However, most studies used Ru-based CORM-2 and/or CORM-3 as CO sources, despite their known chemical reactivity and idiosyncratic CO release. Herein, we conducted studies using one of the most widely used probes (FL-CO-1), evaluating its response to various CO sources and to Pd(0). We found that (1) the activation of FL-CO-1 by CORM-2/-3 has CO-independent component(s); (2) vitamin C and cysteine were found to interfere with the probe's performance; and (3) Pd(0) only led to moderate fluorescence turn-on, while a combination of Pd(0) and CO resulted in a pronounced fluorescence turn-on response. Such find

SUBMITTER: Liu D 

PROVIDER: S-EPMC12624833 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature