Nitric oxide-releasing PHEMA/polysilsesquioxane photocrosslinked hybrids.

ABSTRACT: Polymeric materials capable of releasing nitric oxide (NO) locally have potential uses in various biomedical applications. One of the main challenges in this field is obtaining materials that allow the modulation of NO release rates through the incorporation of different NO donor molecules. Herein, we describe the synthesis of materials composed of poly(2-hydroxyethyl methacrylate) (PHEMA) crosslinked by a polysilsesquioxane (PSS) network through sol-gel polymerization and photocrosslinking. Increasing the PSS content from 5 to 20 wt% led to an increase in the glass transition temperature from 107 °C to 133 °C. Swelling studies in phosphate buffer saline solution and ethanol revealed that higher siloxane content reduced the solvent uptake of the hybrids, while surface contact angle measure

SUBMITTER: Vieira de Almeida H 

PROVIDER: S-EPMC12624852 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature