QSP-Copilot: An AI-Augmented Platform for Accelerating Quantitative Systems Pharmacology Model Development.

ABSTRACT: Quantitative Systems Pharmacology (QSP) is a powerful approach to provide decision-making support throughout the drug development process. QSP comes with many challenges in model development, validation, and applications. Traditional QSP workflows are limited by slow knowledge integration, labor-intensive model construction, inconsistent validation practices, and restricted scalability. In this work, we introduce QSP-Copilot, the first end-to-end AI-augmented solution designed to improve QSP modeling workflows by integrating a multi-agent system utilizing large language models (LLMs). QSP-Copilot provides modular support from project scoping and model structuring to model evaluation and reporting. Through the automation of routine tasks, QSP-Copilot reduces model development time by approx

SUBMITTER: Saini A 

PROVIDER: S-EPMC12625087 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature