Gender Is the Main Predictor of Wearing-Off and Dyskinesia in Levodopa-Naive Patients with Parkinson's Disease.

ABSTRACT:

Background

Evidence suggests that female gender represents a risk factor for the development of motor/nonmotor fluctuations and dyskinesia in Parkinson's disease (PD). So far, no prospective study has analyzed this aspect in relation to the introduction of levodopa treatment.

Objective

This prospective multicenter study aims to assess the development of motor/nonmotor fluctuations and dyskinesia based on gender over a 2-year observation period in PD patients starting levodopa.

Methods

Two hundred and eighty-nine PD patients requiring levodopa at baseline were enrolled at 17 Movement Disorders Centers and followed for 2 years. Gender differences in the development of fluctuations, defined as a score ≥2 in the 19-item Wearing-Off Questionnaire, and dyskinesia, defined b

SUBMITTER: Pellecchia MT 

PROVIDER: S-EPMC12625146 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature