Associations of mucus plugging, small airway dysfunction, and airway wall thickening in cough-variant asthma versus asthma.

ABSTRACT:

Background

Mucus plugs have been implicated in airflow obstruction in asthma and chronic obstructive pulmonary disease (COPD). However, the role of mucus plugs in cough-variant asthma (CVA) remains understudied, and their associations with classic asthma (CA), CVA, and small airway dysfunction (SAD) are poorly defined. This retrospective cohort study aimed to evaluate the relationship between mucus plugs and lung function in CA and CVA patients, and to investigate their correlations with quantitative CT-derived airway wall thickness parameters.

Methods

A total of 109 CVA patients and 65 CA patients were enrolled. Clinical characteristics, laboratory parameters, quantitative CT data, and pulmonary function metrics were systematically collected. Airway structural measurements,

SUBMITTER: Wang K 

PROVIDER: S-EPMC12625180 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature